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Multislice CT in graft vascular disease. A pilot study.

J Moro¹, L Almenar, B Igual

¹Cardiology Department La Fe University Hospital, Valencia, Spain. moro@uv.es

Transplantation Proceedings

|November 14, 2006

Summary

Multislice CT shows promise for detecting graft vessel disease (GVD) in heart transplant patients, offering a high negative predictive value. This non-invasive technique aids in screening for GVD, potentially reducing the need for invasive diagnostic procedures.

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Published on: July 16, 2018

Area of Science:

Cardiology
Radiology
Transplant Medicine

Background:

Graft vessel disease (GVD) is a major long-term complication following heart transplantation (HT).
Current GVD diagnosis relies on invasive methods, highlighting the need for alternative techniques.
Multislice CT (MSCT) offers non-invasive visualization of coronary anatomy, including lumen and wall thickness.

Purpose of the Study:

To evaluate the diagnostic value of 16-detector multislice CT (MSCT) for detecting GVD in HT patients.
To compare MSCT findings against traditional invasive methods like angiography and intravascular ultrasound (IVUS).

Main Methods:

A study involving 32 heart transplant patients with a mean follow-up of 2016 days.
16-detector MSCT was performed within 24 hours before angiography.
IVUS was used for confirmation when angiography results were normal; statistical analysis determined sensitivity, specificity, and predictive values.

Main Results:

The study included 30 patients for CT assessment after exclusions.
MSCT demonstrated a sensitivity of 50%, specificity of 81%, negative predictive value of 81%, positive predictive value of 50%, and precision of 72% compared to invasive methods.
A high negative predictive value suggests MSCT's effectiveness in ruling out GVD.

Conclusions:

16-detector MSCT shows good performance for screening GVD in heart transplant recipients.
The technique's high negative predictive value supports its utility in identifying patients without GVD.
Future research will involve larger cohorts and advanced 64-detector CT for improved resolution.