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Related Experiment Video

Updated: Jul 18, 2026

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
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A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

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Agonal period in potential non-heart-beating donors.

S Sohrabi1, A Navarro, J Asher

  • 1Liver and Renal Transplant Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom. so_sor@yahoo.co.uk

Transplantation Proceedings
|November 14, 2006
PubMed
Summary

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The increasing shortage of donor kidneys necessitates using non-heart-beating (NHB) donors. While kidneys from NHB donors can be transplanted after prolonged waiting periods, logistical challenges limit utilization.

Area of Science:

  • Nephrology
  • Transplantation Surgery
  • Organ Donation

Background:

  • Donor kidney shortage is a critical issue in renal transplantation.
  • Non-heart-beating (NHB) donors are increasingly utilized to address organ scarcity.
  • Protracted agonal periods in NHB donors raise concerns about organ quality.

Purpose of the Study:

  • To retrospectively audit the maximal duration of the agonal period for Maastricht category NHB donors after treatment withdrawal in Newcastle.
  • To evaluate the impact of agonal period duration on kidney non-use rates and transplant outcomes.

Main Methods:

  • Retrospective audit of 58 kidneys from NHB donors.
  • Analysis of kidney non-use rates based on the duration of the agonal period (0-2 hours, 2-5 hours, >5 hours).

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  • Statistical comparison of non-use rates between different time intervals.

    • Main Results:

    • Kidney non-use rates were 13% (0-2 hours), 33% (2-5 hours), and 45% (>5 hours).
    • A significant difference in non-use rates was observed between the 0-2 hour and >5 hour groups (P < .05).
    • Despite longer waiting times, 16 transplants used kidneys >2 hours and 12 used kidneys >5 hours.

    Conclusions:

    • Usable kidneys can be obtained from NHB donors even with protracted withdrawal periods.
    • A 5-hour cut-off for agonal period duration presents logistical difficulties.
    • The current 5-hour cut-off results in the non-utilization of approximately one-third of potential donor kidneys.