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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Related Experiment Video

Updated: Jul 18, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Living kidney donors developing end-stage renal disease.

I Fehrman-Ekholm1, G Nordén, A Lennerling

  • 1Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Göteborg, Sweden. ingela.fehrman-ekholm@vgregion.se

Transplantation Proceedings
|November 14, 2006
PubMed
Summary

Living kidney donors face a risk of end-stage renal failure (ESRF) years after donation. This study found at least six donors developed ESRF, highlighting the importance of long-term donor monitoring.

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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Published on: July 15, 2015

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Last Updated: Jul 18, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

Area of Science:

  • Nephrology
  • Transplantation Surgery
  • Public Health

Background:

  • Living kidney donation is a vital procedure for end-stage renal failure (ESRF) patients.
  • Long-term outcomes for living kidney donors require ongoing investigation.
  • Understanding donor risks is crucial for ethical and effective donation programs.

Purpose of the Study:

  • To analyze the incidence of end-stage renal failure (ESRF) in a cohort of living kidney donors.
  • To identify potential risk factors and diagnoses associated with ESRF post-donation.
  • To inform long-term follow-up protocols for kidney donors.

Main Methods:

  • Retrospective analysis of 1112 living kidney donors who underwent nephrectomy between 1965 and 2005.
  • Follow-up to determine the development of ESRF.
  • Review of medical records for diagnoses leading to ESRF.

Main Results:

  • At least six donors (0.54%) developed ESRF 14-27 years post-donation (median 20 years).
  • Five of the six affected donors were male.
  • Diagnoses included nephrosclerosis (4), postrenal failure (1), and renal carcinoma (1).

Conclusions:

  • Living kidney donation carries a long-term risk of end-stage renal failure.
  • Nephrosclerosis appears to be a significant cause of ESRF in this donor cohort.
  • Extended follow-up is warranted for living kidney donors to monitor for ESRF.