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Living kidney donors developing end-stage renal disease
I Fehrman-Ekholm1, G Nordén, A Lennerling
1Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Göteborg, Sweden. ingela.fehrman-ekholm@vgregion.se
Transplantation Proceedings
|November 14, 2006
Summary
Living kidney donors face a risk of end-stage renal failure (ESRF) years after donation. This study found at least six donors developed ESRF, highlighting the importance of long-term donor monitoring.
Area of Science:
- Nephrology
- Transplantation Surgery
- Public Health
Background:
- Living kidney donation is a vital procedure for end-stage renal failure (ESRF) patients.
- Long-term outcomes for living kidney donors require ongoing investigation.
- Understanding donor risks is crucial for ethical and effective donation programs.
Purpose of the Study:
- To analyze the incidence of end-stage renal failure (ESRF) in a cohort of living kidney donors.
- To identify potential risk factors and diagnoses associated with ESRF post-donation.
- To inform long-term follow-up protocols for kidney donors.
Main Methods:
- Retrospective analysis of 1112 living kidney donors who underwent nephrectomy between 1965 and 2005.
- Follow-up to determine the development of ESRF.
- Review of medical records for diagnoses leading to ESRF.
Main Results:
- At least six donors (0.54%) developed ESRF 14-27 years post-donation (median 20 years).
- Five of the six affected donors were male.
- Diagnoses included nephrosclerosis (4), postrenal failure (1), and renal carcinoma (1).
Conclusions:
- Living kidney donation carries a long-term risk of end-stage renal failure.
- Nephrosclerosis appears to be a significant cause of ESRF in this donor cohort.
- Extended follow-up is warranted for living kidney donors to monitor for ESRF.
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