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Updated: Jul 18, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Tenascin is expressed in post-transplant obliterative bronchiolitis
O Päiväniemi1, H Alho, P Maasilta
1Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland.
Tenascin expression is linked to airway obliteration in post-transplant obliterative bronchiolitis (OB). This study shows tenascin contributes to inflammation and fibroblast proliferation, driving OB development in bronchial allografts.
Area of Science:
- Immunology
- Cell Biology
- Transplantation Science
Background:
- Tenascin is involved in inflammatory and fibroproliferative conditions.
- Post-transplant obliterative bronchiolitis (OB) involves epithelial injury and airway obliteration.
Purpose of the Study:
- To investigate the role of tenascin in the alloimmune response leading to OB in bronchial allografts.
- To understand tenascin's contribution to inflammation and fibrosis in OB.
Main Methods:
- Bronchial allografts and autografts were implanted in pigs.
- Serial sampling for histology and immunocytochemistry (CD4, CD8, tenascin).
- Grading of findings on a scale of 0 to 3.
Main Results:
- Allografts showed progressive epithelial loss and luminal obliteration by day 21.
- Significant increase in inflammatory cells (CD4+, CD8+) by day 14.
- Early tenascin expression (day 7) in epithelial cells (69%) and bronchial walls, correlating with fibroproliferation.
Conclusions:
- Tenascin expression is elevated during the early inflammatory and fibroproliferative stages of OB.
- Tenascin plays a role in the development of post-transplant obliterative bronchiolitis.
- Targeting tenascin may offer therapeutic potential for OB.
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