Related Experiment Video
Updated: Jul 18, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
Appendiceal outer diameter as an indicator for differentiating appendiceal mucocele from appendicitis
Wan-Ching Lien1, Shih-Pei Huang, Chun-Lin Chi
1Department of Emergency Medicine, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei 100, Taiwan.
Background:
Patients with appendiceal mucocele (AM) commonly present with features indicative of acute appendicitis. In emergency departments, accurate preoperative diagnosis is crucial to prompt appropriate treatment. This study investigates the clinical and sonographic characteristics of AM, which may prove useful in preoperatively differentiating AM from appendicitis.
Methods:
This case-control study compares the clinical and sonographic findings of 16 histologically confirmed AM with sex- and age-matched control subjects (n = 64) with appendicitis by a 1:4 ratio. Conditional logistic regression was applied to estimate the odds ratio (OR) and 95% confidence intervals (CI) of clinical and sonographic parameters associated with AM.
Results:
Univariate analysis demonstrated that the larger appendiceal outer diameter by sonography was positively correlated with diagnosis of AM (OR, 2.31; 95% CI, 1.42-3.72) and right lower quadrant abdominal pain was negatively correlated (OR, 0.38; 95% CI, 0.17-0.82). However, multiple regression analysis suggested that only outer diameter remained significant (OR, 2.21; 95% CI, 1.36-3.59) after adjusting for age, sex, and right lower quadrant pain. An outer diameter of 15 mm or more was predictive of AM diagnosis, with a sensitivity of 83% and specificity of 92%.
Conclusion:
When the threshold is set at 15 mm, appendiceal outer diameter by sonography is a useful preoperative measurement for differentiating between AM and acute appendicitis.
Insights
Appendiceal mucocele (AM) can mimic appendicitis. Sonographic outer diameter ≥15 mm effectively differentiates AM from appendicitis, aiding preoperative diagnosis and treatment planning.
Area of Science:
- Gastroenterology
- Radiology
- Surgical Pathology
Background:
- Appendiceal mucocele (AM) often presents with symptoms similar to acute appendicitis.
- Accurate preoperative diagnosis is essential for appropriate emergency department management.
- Differentiating AM from appendicitis preoperatively can guide treatment decisions.
Purpose of the Study:
- To identify clinical and sonographic features distinguishing appendiceal mucocele (AM) from acute appendicitis.
- To evaluate the utility of sonographic measurements in preoperative differentiation.
Main Methods:
- A case-control study compared 16 patients with histologically confirmed AM to 64 age- and sex-matched patients with appendicitis.
- Conditional logistic regression analyzed clinical and sonographic parameters.
- Odds ratios (OR) and 95% confidence intervals (CI) were calculated.
Main Results:
- Sonographic appendiceal outer diameter positively correlated with AM (OR, 2.31).
- Right lower quadrant pain was negatively correlated with AM (OR, 0.38).
- An outer diameter ≥15 mm demonstrated 83% sensitivity and 92% specificity for AM.
Conclusions:
- Appendiceal outer diameter measured by sonography is a valuable preoperative tool.
- A threshold of 15 mm for outer diameter effectively differentiates AM from acute appendicitis.
Related Concept Videos
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Diverticular Disease of the Colon
Assessment of the Abdomen II: Percussion
Percussion
Percussion is an essential...
