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A CTL epitope on the circumsporozoite protein of P. yoelii
W R Weiss1, R A Houghten, M F Good
1Infectious Disease Department, Naval Medical Research Institute, Bethesda, MD 20814-5055.
Bulletin of the World Health Organization
|January 1, 1990
Abstract:
Humans are infected with malaria by the bite of anophelene mosquitos carrying plasmodia sporozoites. These sporozoites pass quickly from the blood into hepatocytes, where they develop into mature liver-stage parasites over several days. The clinical stage of the illness begins only when the liver-stage parasites rupture into the bloodstream and erythrocytes are invaded. The pre-erythrocytic stages of malaria are inviting targets for vaccine development, because an effective immune response to these early stages would prevent symptomatic infections.