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Updated: Jul 18, 2026

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
[Sirt1: a novel adipocyte and myocyte regulatory factor]
Liang Bai1, Wei-Jun Pang, Gong-She Yang
1Laboratory of Animal Fat Deposition and Muscle Development, Northwest A & F University, Yangling 712100, China. bailiang0922@gmail.com
Abstract:
Sirt1 (Sirtuin type 1), a member of the conserved sirtuin family, is a NAD+ -dependent histone deacetylase. It is intimately related to cell proliferation, differentiation, apoptosis, and metabolism. Its role in senescence and metabolism has recently come to light. Sirt1 promotes fat mobilization in white adipocytes by repressing PPARgamma and inhibits myoblast differentiation by down-regulating muscle gene expression. Therefore, Sirt1 is not only an important longevity factor, but also may play a key modulatory role in animal fat deposition and muscle development.
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