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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria

Jerome S Pinkner1, Han Remaut, Floris Buelens

  • 1Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 14, 2006
PubMed
Summary

New pilicides effectively inhibit the assembly of adhesive pili in Gram-negative pathogens like E. coli, reducing virulence factors by 90%. This discovery offers a promising strategy for developing novel anti-virulence drugs.

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