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Human normal B lymphocytes produce a growth-promoting activity for granulocyte progenitors in diffusion chamber
J Hansz1, M Kozłowska-Skrzypczak
1Department of Haematology, Academy of Medicine, Poznán, Poland.
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1990
Abstract:
We have measured the effect of normal B lymphocytes on more primitive granulocyte progenitors (CFU-dG) clonal growth in double-diffusion chamber culture in vivo. It was found that pokeweed mitogen (PWM) stimulated B cells produce a growth-promoting activity which augments the CFU-dG--derived myeloid colony formation in a dose-dependent fashion. All colonies formed under the experimental conditions were composed exclusively of granulocytes at different stages of maturation. Unstimulated B lymphocytes did not effect the CFU-dG clonal proliferation.