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Related Experiment Videos

Mannose-binding lectin levels during pregnancy: a longitudinal study.

F E van de Geijn1, A Roos, Y A de Man

  • 1Department of Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. f.vandegeijn@erasmusmc.nl

Human Reproduction (Oxford, England)
|November 14, 2006
PubMed
Summary

Pregnancy significantly alters mannose-binding lectin (MBL) levels, increasing them during gestation and decreasing them postpartum. These MBL changes directly impact complement pathway activity, highlighting innate immunity adaptations during pregnancy.

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Area of Science:

  • Immunology
  • Maternal-fetal medicine

Background:

  • Pregnancy involves significant immune system adaptations.
  • Innate immunity, particularly mannose-binding lectin (MBL), may play a role in pregnancy outcomes.
  • Limited research exists on pregnancy-related changes in innate immunity.

Purpose of the Study:

  • To investigate the influence of pregnancy on mannose-binding lectin (MBL) concentrations.
  • To assess the impact of pregnancy on MBL-associated complement pathway activation.

Main Methods:

  • Sera from 32 pregnant women across trimesters and postpartum were analyzed using ELISA.
  • Measurements included MBL, Ficolin-2 concentrations, MBL-MASP complex activity, and MBL/classical complement pathway activity.
  • MBL genotyping was performed using PCR.

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Main Results:

  • MBL concentrations increased by 140% during pregnancy, evident by 12 weeks and most pronounced in the AA-genotype.
  • Postpartum, MBL levels dropped to 57% of baseline.
  • Changes in MBL levels strongly correlated with complement activation (r > 0.93).
  • Ficolin-2 levels and classical complement pathway activity remained unaffected by pregnancy.

Conclusions:

  • Pregnancy and the postpartum period significantly alter serum MBL concentrations.
  • These alterations profoundly influence MBL-mediated complement pathway activity.