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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

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Related Experiment Video

Updated: Jul 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Systemic lupus erythematosus and pregnancy.

Yair Molad1

  • 1Rheumatology Unit, Rabin Medical Center, Beilinson Campus, Petah Tiqwa and Internal Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ymolad@clalit.org.il

Current Opinion in Obstetrics & Gynecology
|November 14, 2006
PubMed
Summary

For most women with stable systemic lupus erythematosus (SLE), pregnancy is safe. Careful pre-pregnancy evaluation and monitoring are crucial for managing lupus during pregnancy and ensuring positive maternal and fetal outcomes.

Related Experiment Videos

Last Updated: Jul 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

  • Reproductive immunology
  • Maternal-fetal medicine
  • Rheumatology

Background:

  • Pregnancy in patients with systemic lupus erythematosus (SLE) carries risks of maternal disease flares and adverse fetal outcomes.
  • Recent research has focused on understanding and mitigating these risks.

Purpose of the Study:

  • To review recent published findings on pregnancy in patients with SLE.
  • To summarize current understanding of risks, outcomes, and management strategies.

Main Methods:

  • Literature review of recent publications on lupus pregnancy.
  • Synthesis of findings regarding safety, risk factors, and management.

Main Results:

  • Pregnancy is generally safe for women with inactive and stable SLE.
  • Key risk factors for adverse outcomes include active disease, nephritis, hypertension, and specific maternal autoantibodies (e.g., anti-Ro/La, lupus anticoagulant).
  • New insights into the immunological mechanisms of congenital heart block and modified approaches to oral contraceptive use in SLE patients have emerged.

Conclusions:

  • Pregnancy is manageable in SLE patients with stable disease.
  • Pre-gestational risk assessment and close monitoring during pregnancy are essential.
  • Lupus flares during pregnancy can typically be managed safely.