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Related Experiment Video

Updated: Jul 18, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy.

Lian Tock¹, Wagner L Prado, Danielle A Caranti

¹Federal University of São Paulo, Paulista Medicine School, UNIFESP, EPM, São Paulo, Brazil.

European Journal of Gastroenterology & Hepatology

|November 14, 2006

Summary

A 12-week multidisciplinary therapy significantly reduced visceral adiposity and nonalcoholic fatty liver disease (NAFLD) in obese adolescents. This intervention shows promise for managing obesity-related comorbidities in young individuals.

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Area of Science:

Pediatrics
Hepatology
Obesity Medicine

Background:

Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, yet its development and importance are not fully understood, with no definitive treatment available.
Obesity-related comorbidities pose significant health challenges in pediatric populations.

Purpose of the Study:

To evaluate the short-term (12-week) effects of a multidisciplinary therapy on visceral adiposity and NAFLD control in obese adolescents.
To assess the impact of non-pharmacological interventions on metabolic health in a young population.

Main Methods:

Seventy-three obese adolescents (aged 17.01±1.6 years, BMI 36.54±2.86 kg/m²) underwent a 12-week multidisciplinary, non-pharmacological treatment.
Visceral adiposity and NAFLD were assessed using ultrasonography at baseline and after the intervention period.
Statistical analyses included descriptive statistics, one-way ANOVA, and paired t-tests.

Main Results:

The intervention led to a significant reduction in visceral adiposity (from 4.05±1.55 to 3.37±1.44).
NAFLD prevalence decreased significantly, from 52% to 29% on the right liver lobe and 48% to 29% on the left.
These findings are crucial as NAFLD can progress to cirrhosis, even in children and adolescents.

Conclusions:

Short-term multidisciplinary therapy demonstrates a substantial positive impact on controlling obesity-related comorbidities in adolescents.
This approach offers a promising strategy for managing NAFLD and associated conditions in young individuals.