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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jul 18, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Nucleic acid based therapeutics for tumor therapy.

Manfred Ogris1

  • 1Pharmaceutical Biology-Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität, Butenandtstr 5-13, Munich, Germany. Manfred.Ogris@cup.uni-muenchen.de

Anti-Cancer Agents in Medicinal Chemistry
|November 15, 2006
PubMed
Summary

Novel macromolecular therapeutics utilize cancer

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Oncology

Background:

  • Cancer is a heterogeneous disease with unique features exploitable for macromolecular therapeutics.
  • Tumor cell proliferation, vasculature, and leaky vessels facilitate targeted delivery of nucleic acids.
  • Polycationic gene carriers (polyplexes) are developed for nucleic acid delivery, with enhanced understanding of cellular interactions.

Purpose of the Study:

  • To explore the potential of polycationic gene carriers for targeted cancer therapy.
  • To investigate the incorporation of virus-like domains to enhance polyplex functionality.
  • To evaluate physical targeting strategies for improving nucleic acid transfer efficiency.

Main Methods:

  • Development of polycationic gene carriers (polyplexes) for nucleic acid delivery.

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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  • Incorporation of virus-like domains: hydrophilic shielding, targeting ligands, and membrane-active peptides.
  • Application of physical targeting methods: locoregional hyperthermia and photochemical internalization (PCI).

    • Main Results:

    • Demonstrated successful targeted delivery of nucleic acids into tumor tissues.
    • Showcased enhanced cellular uptake and intracellular trafficking via modified polyplexes.
    • Achieved eradication of intracranial glioblastoma in mouse models using local double-stranded RNA application.
    • Reported promising initial results for a gene-directed enzyme prodrug approach for cyclophosphamide activation.

    Conclusions:

    • Polycationic gene carriers with incorporated virus-like domains show promise for cancer therapy.
    • Physical targeting strategies significantly enhance the efficiency of nucleic acid delivery.
    • Therapeutic strategies involving nucleic acids and gene-directed enzyme prodrugs offer potential for cancer treatment.