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Updated: Jul 18, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Minimisation of palladium content in Suzuki cross-coupling reactions
Heather Tye1, Mark Whittaker, Shailesh Ramdeehul
1Evotec (UK) Ltd., 111 Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK. heather.tye@evotec.com
Abstract:
A protocol for conducting Suzuki reactions in a plate format amenable to use in library synthesis of biaryl compounds has been developed. A key objective was to determine reaction conditions which give biaryl products containing <10 ppm of Pd for a wide variety of building blocks. A Design of Experiments (DoE) approach for the identification of an optimised set of reaction conditions was successfully applied. The utility of the protocol developed has been demonstrated by preparation of an array of 96 biaryl compounds in a parallel fashion.
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