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Complete mole coexistent with a twin fetus
Tomonori Ogura1, Hidenori Katoh, Shoji Satoh
1Department of Gynecology and Obstetrics, Faculty of Medicine, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan. ogura@med.kyushu-u.ac.jp
The Journal of Obstetrics and Gynaecology Research
|November 15, 2006
Summary
This study presents two cases of complete hydatidiform mole coexisting with a live fetus. DNA analysis confirmed the mole
Area of Science:
- Reproductive Medicine
- Genetics
- Obstetrics
Background:
- Complete hydatidiform mole (CHM) is a placental tumor with genetic abnormalities.
- Coexistence of CHM with a live fetus is rare and poses diagnostic challenges.
Observation:
- Two pregnant women presented with symptoms suggestive of pre-eclampsia and ultrasound findings of a multicystic placental mass alongside a live fetus.
- One case involved a 16-week gestation with a hydropic placenta and normal fetus, requiring evacuation. The second case at 20 weeks gestation had a normal placenta with a coexistent multicystic mass, necessitating hysterotomy due to bleeding.
Findings:
- DNA polymorphism analysis was performed on placental tissue, tumor, and maternal/paternal blood.
- Genetic analysis confirmed the placental tumor was of paternal origin in both cases, consistent with complete hydatidiform mole.
Implications:
- This confirms the utility of DNA analysis in diagnosing coexistent complete hydatidiform mole and live fetus.
- Accurate diagnosis is crucial for appropriate management and patient care in these rare obstetric complications.
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