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Updated: Jul 18, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Allergic contact dermatitis from oleyl alcohol in Elidel cream
Klaus Ejner Andersen1, Sigurd Broesby-Olsen
1Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, DK-5000, Odense, Denmark. keandersen@health.sdu.dk
Abstract:
We report an atopic dermatitis patient with recurrent hand dermatitis who developed a severe allergic contact dermatitis from the use of Elidel cream. Diagnostic patch tests showed an isolated contact allergy to the emulsifier oleyl alcohol present in the product. Pimecrolimus appeared to have had an aggravating effect on the dermatitis in spite of its immunosuppressive effects. The initial clinical appearance of the patient's widespread dermatitis was atypical with resemblance to subacute cutaneous lupus erythematosus. Even though emulsifiers are widely used in topical products, contact allergic reactions to these are relatively uncommon.
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