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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jul 18, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Ophthalmodynamometric differences between ischemic vs nonischemic retinal vein occlusion.

Jost B Jonas1, Bjoern Harder

  • 1Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, Ruprecht-Karls-University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Jost.Jonas@augen.ma.uni-heidelberg.de

American Journal of Ophthalmology
|November 15, 2006
PubMed
Summary

Central retinal vein pressure is significantly higher in ischemic central retinal vein occlusion (CRVO) compared to nonischemic CRVO and control groups. This finding aids in differentiating CRVO types.

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Doppler Optical Coherence Tomography of Retinal Circulation
10:46

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Published on: September 18, 2012

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Last Updated: Jul 18, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

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Published on: August 6, 2021

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Area of Science:

  • Ophthalmology
  • Vascular Medicine

Background:

  • Central retinal vein occlusion (CRVO) is a serious vascular event affecting vision.
  • Differentiating between ischemic and nonischemic CRVO is crucial for prognosis and treatment.

Purpose of the Study:

  • To estimate and compare central retinal vein pressure in patients with ischemic CRVO, nonischemic CRVO, and healthy controls.
  • To assess the utility of ophthalmodynamometry in distinguishing CRVO subtypes.

Main Methods:

  • A prospective observational study involving 28 CRVO patients (7 ischemic, 21 nonischemic) and 38 controls.
  • Utilized a novel ophthalmodynamometer with a pressure sensor to indirectly measure central retinal artery and vein pressure.

Main Results:

  • Significantly higher central retinal vein pressure was observed in ischemic CRVO (91.5 AU) compared to nonischemic CRVO (52.4 AU) and controls (4.8 AU).
  • Central retinal artery pressure was lower in ischemic CRVO (46.0 AU) than nonischemic CRVO (64.5 AU) and controls (79.9 AU).
  • Vein pressure exceeded diastolic arterial pressure in 100% of ischemic CRVO cases versus 38% in nonischemic CRVO.

Conclusions:

  • Ophthalmodynamometry can help differentiate between ischemic and nonischemic CRVO.
  • In ischemic CRVO, vein pulsations were frequently noted at supradiastolic arterial pressures.