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Expression of nuclear retinoic acid receptors in rat adipose tissue

R Haq1, F Chytil

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.

Biochemical and Biophysical Research Communications
|May 15, 1991
PubMed

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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes: