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Abnormal development of pacinian corpuscles in double trkB;trkC knockout mice
F de Carlos1, J Cobo, G Germanà
1Departamentos de Cirugía y Especialidades Medico-Quirúrgicas, Universidad de Oviedo, Spain.
Neuroscience Letters
|November 15, 2006
Summary
The Trk-neurotrophin system, particularly TrkB, regulates Pacinian corpuscle development in mice. Genetic mutations affecting TrkB and TrkC receptors impact corpuscle structure and survival.
Area of Science:
- Neuroscience
- Developmental Biology
- Cell Biology
Background:
- Pacinian corpuscles are mechanoreceptors crucial for tactile sensation.
- Their development and maintenance rely on Aalpha and Abeta nerve fibers.
- These nerve fibers express TrkB and TrkC neurotrophin receptors.
Purpose of the Study:
- To investigate the role of TrkB and TrkC in Pacinian corpuscle development.
- To analyze the impact of single and double gene mutations on corpuscle integrity.
Main Methods:
- Immunohistochemistry and ultrastructural analysis were performed on 25-day-old mice.
- Targeted mutations in trkB and trkC genes were introduced.
Main Results:
- Single trkB or trkC mutations had minimal effects on Pacinian corpuscles.
- Double mutations (trkB;trkC) resulted in a reduction in corpuscle number.
- A subset of Pacinian corpuscles showed hypoplasia or atrophy in double mutant mice.
Conclusions:
- The Trk-neurotrophin system, especially TrkB, regulates a subset of murine Pacinian corpuscle development.
- This regulation may occur at both neuronal and peripheral levels.
- Further research is needed to clarify the specific roles of each component.
