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Differential liver protein expression during schistosomiasis.

Marina Harvie¹, Thomas William Jordan, Anne Camille La Flamme

¹School of Biological Sciences, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.

Infection and Immunity

|November 15, 2006

Summary

Schistosoma mansoni infection significantly alters liver protein expression, reducing proteins vital for normal liver function and increasing stress-related proteins. These changes may serve as new biomarkers for schistosomiasis disease.

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Area of Science:

Proteomics
Immunology
Hepatology

Background:

Schistosoma mansoni infection triggers an initial protective granulomatous response in the liver.
Chronic infection progresses to liver fibrosis, impacting liver function.
Understanding molecular changes in the liver during schistosomiasis is crucial.

Purpose of the Study:

To investigate the impact of acute schistosomiasis on liver protein expression.
To identify proteins altered during schistosome infection using a proteomic approach.

Main Methods:

Proteomic analysis of liver tissue from infected mice 8 weeks postinfection.
Mass fingerprinting to identify differentially expressed proteins.

Main Results:

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Schistosome infection significantly reduced proteins involved in the citric acid cycle, fatty acid cycle, and urea cycle.
Increased abundance of proteins related to stress responses, acute phase reactants, and structural components.
Altered expression patterns of immunity-related proteins like peroxiredoxin 1, arginase 1, and galectin 1.

Conclusions:

Acute schistosomiasis profoundly impacts specific liver functions at the proteomic level.
Altered protein isoforms and upregulated unique proteins show potential as novel disease markers for schistosomiasis.