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Peripheral neuropathy in primary sjogren syndrome: a population-based study
Lasse G Gøransson1, Anita Herigstad, Anne B Tjensvoll
1Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, Norway. gola@sus.no
Archives of Neurology
|November 15, 2006
Summary
Peripheral neuropathy is common in primary Sjögren syndrome (PSS), often presenting as subclinical demyelinating neuropathy. Small-diameter nerve fiber involvement is infrequent in PSS patients.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Primary Sjögren syndrome (PSS) frequently involves neurological complications.
- Peripheral nervous system (PNS) involvement is a recognized, yet not fully understood, manifestation of PSS.
Purpose of the Study:
- To assess the prevalence and characteristics of peripheral neuropathy in an unselected cohort of PSS patients.
- To specifically investigate small-diameter nerve fiber involvement using modern diagnostic criteria.
Main Methods:
- Cross-sectional study involving 62 PSS patients meeting international criteria.
- Utilized clinical neurologic examinations, conventional nerve conduction studies, and skin punch biopsies.
- Assessed large and small diameter peripheral nerve fiber neuropathy through clinical, electrophysiologic, and morphologic evaluations.
Main Results:
- Clinical examination identified neuropathy in 27% of patients.
- Nerve conduction studies revealed abnormalities in 55%, including motor, sensory, and sensorimotor neuropathies.
- Morphologic criteria for small-diameter nerve fiber neuropathy were met by only two patients.
Conclusions:
- Peripheral neuropathy is a frequent complication in primary Sjögren syndrome.
- The majority of neuropathies in PSS are subclinical and demyelinating.
- Small-diameter nerve fiber neuropathy is uncommon in this patient population.
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