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Updated: Jul 18, 2026

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
Published on: July 27, 2022
Expression and effect of transforming growth factor-alpha and tumor necrosis factor-alpha in human pheochromocytoma
An-Li Tong1, Zheng-Pei Zeng, Han-Zhong Li
1Department of Endocrinology, Peking Union Medical College Hospital, 100730 Beijing, China. zengzhengpei@yahoo.com.cn
Abstract:
This study observed the expression of transforming growth factor-alpha (TGF-alpha) and tumor necrosis factor-alpha (TNF-alpha) in pheochromocytoma (PHEO) tissue and examined their effects on the proliferation and apoptosis of human PHEO cells. The mRNA and protein expressions of TGF-alpha and TNF-alpha were higher in PHEO tissues than in normal adrenal medullary tissues, and their expressions varied with pathological features. TGF-alpha and TNF-alpha stimulated the proliferation of primary human PHEO cells, but had no effect on the cell apoptosis. Both TGF-alpha and TNF-alpha might be involved in the pathogenesis of human PHEO. TNF-alpha needs to be further investigated before its treatment of PHEO can be realized in clinical practice.
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