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Updated: Jul 18, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
Aspects on radionuclide therapy in malignant pheochromocytomas
Eva Forssell-Aronsson1, Peter Bernhardt, Bo Wängberg
1Department of Radiation Physics, Lundberg Laboratory for Cancer Research, Göteborg University, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden. eva.forssell_aronsson@radfys.gu.se
Malignant pheochromocytomas and paragangliomas (PCs/PGs) with metastases can be treated with radionuclide therapy. Preoperative imaging with 123I-MIBG and 111In-DTPA-D-Phe1-octreotide guides personalized radionuclide therapy planning.
Area of Science:
- Nuclear Medicine
- Oncology
- Endocrinology
Background:
- Malignant pheochromocytomas/paragangliomas (PCs/PGs) frequently metastasize to distant sites like bone, liver, and lungs.
- Radionuclide therapy offers a valuable treatment option for disseminated tumors and can be used as adjuvant therapy post-surgery.
Purpose of the Study:
- To evaluate the utility of combined scintigraphy for radionuclide therapy planning in metastatic PCs/PGs.
- To determine the feasibility of personalized radionuclide therapy based on imaging and dosimetry.
Main Methods:
- Preoperative scintigraphy using both 123I-metaiodobenzylguanidine (MIBG) and 111In-DTPA-D-Phe1-octreotide in patients with metastatic PCs/PGs.
- Dosimetric estimation of radiation dose to tumor and critical normal tissues for individual patient dose-planning.
Main Results:
- Combined imaging identifies lesions amenable to radionuclide therapy.
- Personalized dose planning is crucial for optimizing therapeutic effects and minimizing toxicity.
- Therapy with 131I-MIBG and 177Lu-octreotate may be beneficial for select patients.
Conclusions:
- Combined 123I-MIBG and 111In-DTPA-D-Phe1-octreotide scintigraphy is essential for evaluating radionuclide therapy potential in metastatic PCs/PGs.
- Individualized dosimetry and dose planning are critical for successful radionuclide therapy.
- Targeted radionuclide therapies like 131I-MIBG and 177Lu-octreotate show promise for enhanced efficacy and reduced side effects.
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