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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

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Topical thrombin-related corneal calcification.

Hayyam Kiratli1, Murat Irkeç, Sibel Alaçal

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Topical thrombin with high calcium levels caused unusual corneal calcification. Ethylenediaminetetraacetic acid treatment restored clarity, suggesting a link between thrombin, calcium, and corneal opacity.

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Ocular Pharmacology

Background:

  • Corneal calcification is a rare condition.
  • Topical thrombin is used intraoperatively in some ophthalmic procedures.

Observation:

  • A patient developed corneal and anterior lenticular capsule calcification after intraoperative topical thrombin use.
  • Calcification was primarily located in the Bowman layer of the cornea.

Findings:

  • Biopsies confirmed calcification in the Bowman layer.
  • Topical ethylenediaminetetraacetic acid (EDTA) treatment effectively cleared the corneal calcification.
  • Visual acuity improved after cataract surgery.

Implications:

  • Elevated calcium concentrations in topical thrombin may induce acute corneal calcification.
  • EDTA is a potential treatment for thrombin-induced corneal calcification.
  • This case highlights a rare complication of intraoperative topical thrombin use.