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Updated: Jul 18, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffusion tensor magnetic resonance imaging tractography in cognitive disorders.

¹Centre for Neuroimaging Sciences and Department of Psychological Medicine, Institute of Psychiatry PO89, King's College London, De Crespigny Park, London SE5 8AF, UK. m.catani@iop.kcl.ac.uk

Current Opinion in Neurology

|November 15, 2006

Summary

Diffusion tensor magnetic resonance imaging (DT-MRI) tractography enables in vivo study of white matter integrity and neurocognitive networks. This technique allows direct correlation of lesions with symptoms in cognitive disorders, revealing abnormalities not seen with conventional MRI.

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Area of Science:

Neuroimaging
Neuroscience
Medical Physics

Background:

Novel in vivo techniques like diffusion tensor magnetic resonance imaging (DT-MRI) tractography offer unprecedented insights into white matter microstructure.
These methods allow for virtual dissections of large-scale neurocognitive networks in the human brain.

Purpose of the Study:

To review the advantages and limitations of applying DT-MRI to the study of cognitive and behavioral disorders in neurology and psychiatry.
To explore the potential of DT-MRI in understanding the neural basis of these disorders.

Main Methods:

Diffusion tensor magnetic resonance imaging (DT-MRI) tractography for in vivo tracing of white matter connections.
Virtual dissection of neurocognitive networks.
Correlation of imaging findings with clinical symptoms.

Main Results:

DT-MRI has been instrumental in re-exploring white matter tract anatomy and developing connectional models of brain function.
Its application extends beyond classical disconnection syndromes to neurodevelopmental and neurodegenerative disorders.
Abnormalities in white matter, invisible to conventional MRI, can be detected using DT-MRI.

Conclusions:

DT-MRI enables in vivo correlation of disconnecting lesions with clinical symptoms in cognitive disorders.
The disconnection mechanism can be directly tested in cognitive disorders using DT-MRI.
DT-MRI, alone or combined with other MRI techniques, enhances the detection of white matter abnormalities.