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Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Postinfectious glomerulonephritis in renal allograft recipients
Troy J Plumb1, Arthur Greenberg, Stephen R Smith
1Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Transplantation
|November 15, 2006
Summary
Postinfectious glomerulonephritis (PIGN) is a rare complication after kidney transplants. Prompt treatment of infections can restore kidney function without specific PIGN therapies.
Area of Science:
- Nephrology
- Transplantation immunology
- Infectious diseases
Background:
- Postinfectious glomerulonephritis (PIGN) is an uncommon cause of de novo glomerulonephritis after kidney transplantation.
- Only eight cases have been previously reported in medical literature.
Observation:
- Three type 1 diabetic patients developed PIGN post-kidney transplant between 2000-2004.
- Transplant types included cadaveric, simultaneous kidney-pancreas, and living related kidney followed by pancreas.
- Patients were on triple immunosuppression: tacrolimus, mycophenolate mofetil, and prednisone.
Findings:
- An acute decline in allograft function occurred concurrently with a suspected or confirmed infection.
- Renal biopsies showed immune complex glomerulonephritis with PIGN characteristics.
- All patients recovered renal function after infection treatment, without specific glomerulonephritis therapies.
Implications:
- This study adds three new cases to the literature on posttransplant PIGN.
- It highlights the importance of managing infections in kidney transplant recipients.
- Successful outcomes suggest infection control is key in managing PIGN post-transplant.
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