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The epidemiology of paediatric intussusception in Singapore: 1997 to 2004

Irving Charles Boudville1, Kong Boo Phua, Seng Hock Quak

  • 1GlaxoSmithKline Biologicals, Singapore. irving.boudville@gsk.com

Annals of the Academy of Medicine, Singapore
|November 15, 2006
PubMed

Insights

Intussusception (IS) incidence in Singapore children under two years old is decreasing, with no seasonal trends observed. The risk is highest in the first year of life, with males slightly more affected.

Area of Science:

  • Pediatric Epidemiology
  • Vaccine Safety Surveillance
  • Gastrointestinal Health

Background:

  • Rotavirus vaccine withdrawal in 1998 due to intussusception (IS) highlighted the need for robust safety monitoring.
  • Post-marketing surveillance of new rotavirus vaccines relies on accurate local baseline data for intussusception (IS).

Purpose of the Study:

  • To establish baseline epidemiology of intussusception (IS) in children under two years in Singapore.
  • To inform safety monitoring of rotavirus vaccines through understanding IS incidence and trends.

Main Methods:

  • Retrospective review of hospital admissions (1997-2001) and prospective surveillance (2001-2004) for intussusception (IS) in children under two.
  • Utilized the Brighton Collaboration Intussusception Working Group case definition for accurate case identification.

Main Results:

  • Average incidence of intussusception (IS) was 60/100,000 in under-ones and 32/100,000 in under-twos.
  • A downward trend in IS incidence was observed from 1999 to 2004; 92% of cases were in infants under one year.
  • The mean age of IS occurrence increased, and the male-to-female ratio was 1.3:1, with no seasonal variation.

Conclusions:

  • Intussusception (IS) in Singapore shows a decreasing incidence trend without seasonality.
  • While the first year of life has the highest risk, the second year shows an increasing risk for IS.
  • Males exhibit a slightly elevated risk for intussusception (IS).
Abstract

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