Related Experiment Video
Updated: Jul 18, 2026
09:14
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
[Intracranial bleeding in acquired hemophilia]
L Marquardt1, H Haubelt, S Gass
1Neurologische Klinik, Klinikum Ludwigshafen, Ludwigshafen, Germany. lars.marquardt@clneuro.ox.ac.uk
Der Nervenarzt
|November 15, 2006
Summary
Acquired hemophilia, a rare bleeding disorder, can cause intracerebral hemorrhage in adults, a previously undescribed complication. Despite treatment, the patient experienced rebleeding and died from brainstem compression.
Area of Science:
- Hematology
- Neurology
- Autoimmune Diseases
Background:
- Acquired hemophilia is a rare bleeding disorder often associated with autoimmune diseases and malignancies.
- Intracranial hemorrhage is a known but rare complication of acquired hemophilia.
Observation:
- This report details a unique case of acute intracerebral hemorrhage in an adult patient with acquired hemophilia and factor VIII inhibition.
- The patient presented with symptoms indicative of severe bleeding within the brain.
Findings:
- Treatment involved recombinant factor VIIa, surgical hematoma evacuation, and immunosuppressive therapy with cortisone and cyclophosphamide.
- Despite initial improvement, the patient suffered a fatal intracerebral rebleeding event.
Implications:
- This case highlights the potential for severe intracranial bleeding in acquired hemophilia, even in adults.
- It underscores the need for heightened awareness and prompt management of acquired hemophilia presenting with neurological symptoms.
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