Nanofluidic structures for single biomolecule fluorescent detection
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Updated: Jul 18, 2026
10:57
Automated System for Single Molecule Fluorescence Measurements of Surface-immobilized Biomolecules
Published on: November 2, 2009
1School of Applied and Engineering Physics, Cornell University, Ithaca, NY, USA.
Biopolymers
|November 15, 2006
Abstract:
Fluid-filled nanofabricated cavities can be used to increase the spatial resolution of single molecule confocal microscopy based techniques by creating smaller and more uniformly illuminated probe volumes. Such structures may also be used to temporarily stretch single macromolecules, permitting the resolution of molecular details that would otherwise be beyond the capabilities of a diffraction limited system.
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