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[Effect of the stable prostacyclin analog Iloprost on enzyme release during extracorporeal kidney perfusion]
J Schabel1, H J Hütter, H D Pauer
1Universitätsklinik und Poliklinik für Urologie, Bereichs Medizin, Martin-Luther-Universität Halle-Wittenberg.
Zeitschrift Fur Experimentelle Chirurgie, Transplantation, Und Kunstliche Organe : Organ Der Sektion Experimentelle Chirurgie Der Gesellschaft Fur Chirurgie Der DDR
|January 1, 1990
Abstract:
The influence of the stable prostacyclin-analogue Iloprost (Fa. Schering, Berlin) in the enzyme release from extracorporalic perfused kidneys was tested in an experimental investigation. The mechanic hypothermic perfusion was carried out on four different conditions. The estimation of specially cytosolic, lysosomal, and membrane-associated enzymes in the perfusat of the kidneys showed less activities in the Iloprost-protected kidneys. The results after the replantation of the kidneys support the interpretation of the enzyme determinations.