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Hyaluronic acid deposition in cardiac myxomas: localization using a hyaluronate-specific binding protein
B N Hendin1, M T Longaker, W E Finkbeiner
1Department of Pathology, University of California, San Francisco 94143.
Abstract:
Myxomas are the most common primary tumors of the heart. These lesions contain a gelatinous, ground-substancelike material which has been described as glycosaminoglycan in nature. Using a newly developed, cartilage-derived hyaluronic acid-binding protein and a modification of the avidin-biotin immunostaining procedure, we demonstrate that hyaluronic acid is contained in the jellylike material of cardiac myxomas.