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Updated: Jul 18, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
A case of unilateral coronal synostosis in a child with craniofacial microsomia
Michael J Terry1, Jeffrey A Ascherman
1Division of Plastic Surgery, Columbia College of Physicians and Surgeons, Columbia University Medical Center, 161 Fort Washington Avenue, New York, NY 10032, USA
Insights
Craniofacial microsomia patients can develop frontal plagiocephaly. This study documents a rare case of unilateral coronal synostosis, a bone fusion condition, in a child with craniofacial microsomia.
Area of Science:
- Craniofacial Surgery
- Pediatric Neurosurgery
- Medical Genetics
Background:
- Craniofacial microsomia is a complex congenital condition with diverse anomalies.
- Frontal plagiocephaly affects 5-12% of craniofacial microsomia patients.
- The cause of frontal plagiocephaly in these patients is often unclear, typically presenting as deformational plagiocephaly.
Observation:
- Previous literature suggests deformational plagiocephaly in CFM, with no radiographic evidence of craniosynostosis.
- This report details a unique case of CFM with radiologically confirmed unilateral coronal synostosis.
- The patient presented with atypical physical findings, necessitating advanced imaging.
Findings:
- Radiographic confirmation of unilateral coronal synostosis in a patient with CFM.
- This case challenges the typical understanding of frontal plagiocephaly etiology in CFM.
- Distinguishing between deformational and synostotic plagiocephaly is crucial for appropriate management.
Implications:
- Highlights the importance of thorough radiographic evaluation in CFM patients with plagiocephaly.
- Suggests a potential link between CFM and true craniosynostosis, not just positional molding.
- Informs diagnostic and treatment strategies for complex craniofacial anomalies.
Abstract:
Craniofacial microsomia is a congenital malformation complex associated with a wide array of craniofacial and extracraniofacial anomalies. Frontal plagiocephaly has been shown to occur in approximately 5% to 12% of patients with craniofacial microsomia. The etiology of craniofacial microsomia-associated frontal plagiocephaly is unclear; of the cases described in the literature, all but one had physical findings suggestive of deformational plagiocephaly. In the case with equivocal physical findings, radiographic studies showed no evidence of craniosynostosis. Unlike the above cases, we report a documented case of radiologically-confirmed unilateral coronal synostosis in a child with craniofacial microsomia.
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