Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IgA antibody immunotherapy targeting GD2 is effective in preclinical neuroblastoma models.

Journal for immunotherapy of cancer·2023
Same author

Human monoclonal antibodies against <i>Staphylococcus aureus</i> surface antigens recognize in vitro and in vivo biofilm.

eLife·2022
Same author

Within-patient comparison between [<sup>68</sup>Ga]Ga-tilmanocept PET/CT lymphoscintigraphy and [<sup>99m</sup>Tc]Tc-tilmanocept lymphoscintigraphy for sentinel lymph node detection in oral cancer: a pilot study.

European journal of nuclear medicine and molecular imaging·2021
Same author

Targeting of promising transmembrane proteins for diagnosis and treatment of pancreatic ductal adenocarcinoma.

Theranostics·2021
Same author

Diagnostic accuracy of [<sup>99m</sup> Tc]Tc-tilmanocept compared to [<sup>99m</sup> Tc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2021
Same author

In Vivo Retention Quantification of Supramolecular Hydrogels Engineered for Cardiac Delivery.

Advanced healthcare materials·2021

Related Experiment Video

Updated: Jul 18, 2026

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

Lanthanide-loaded liposomes for multimodality imaging and therapy.

Sander W Zielhuis1, Jan-Henry Seppenwoolde, Vanessa A P Mateus

  • 1Department of Nuclear Medicine, University Medical Center, Utrecht, The Netherlands.

Cancer Biotherapy & Radiopharmaceuticals
|November 16, 2006
PubMed
Summary

Nanosized liposomes were developed for dual-purpose molecular imaging and radionuclide therapy. These liposomes, labeled with holmium-166 or technetium-99m and gadolinium, enable multimodality SPECT and MRI, alongside targeted cancer treatment.

More Related Videos

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
08:44

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Published on: July 30, 2020

Related Experiment Videos

Last Updated: Jul 18, 2026

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
08:44

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Published on: July 30, 2020

Area of Science:

  • Molecular imaging and targeted therapy.
  • Nanotechnology in drug delivery and diagnostics.

Background:

  • Liposomes are promising carriers for diagnostic and therapeutic agents.
  • Advanced molecular imaging agents are under preclinical investigation.
  • Multimodality imaging offers enhanced diagnostic capabilities.

Purpose of the Study:

  • To design and characterize nanosized liposomes for multimodality SPECT and MR imaging.
  • To develop a single agent for both diagnostic imaging and radionuclide therapy.
  • To evaluate the incorporation of radionuclides and gadolinium for enhanced imaging and therapeutic potential.

Main Methods:

  • Liposomes were synthesized incorporating diethylenetriaminepentaacetic acid bisoctadecylamide and gadoliniumacetylacetonate (GdAcAc).
  • Liposomes were labeled with holmium-166 or technetium-99m.
  • Characterization included size, gadolinium content, radiochemical stability, and in vitro MRI relaxivity measurements.

Main Results:

  • Successful labeling of liposomes with holmium-166 (95% efficiency) and technetium-99m (85% efficiency) was achieved.
  • High radiochemical stability was confirmed for both radionuclide-labeled liposomes.
  • GdAcAc incorporation significantly enhanced MRI relaxivity, indicating potent imaging capabilities.

Conclusions:

  • The synthesized liposomes effectively enable multimodality imaging (SPECT/MRI) and radionuclide therapy.
  • These novel agents hold significant promise for future clinical applications in cancer treatment and diagnostics.