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Updated: Jul 13, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
Published on: January 25, 2018
Gamma-secretase as a pharmacological target in Alzheimer disease research: when, why and how?
Chewki Ziani-Cherif1, Bachir Mostefa-Kara, Fatima Z Brixi-Gormat
1Laboratoire de Catalyse et Chimie Fine, Université Abou Bekr Belkaid, B.P.119, Tlemcen 13000, Algeria. czcherif@yahoo.fr
Abstract:
Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (Abeta peptides) in the form of senile plaques as well as neurofibrillary tangles (NFTs) in the brain. In the amyloidogenic pathway, the amyloid-beta precursor protein (APP) is cleaved by beta-secretase first, followed by gamma-secretase cleavage producing therefore Abeta. This review summarizes the recent findings in the AD field and focuses on the different gamma-secretase inhibitors that have been developed as a therapeutic approach toward AD.
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