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Updated: Jul 18, 2026
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
Inactivation of a European strain of West Nile virus in single- donor platelet concentrate using the INTERCEPT blood
P Gallian1, C Vignoli, A M Dombey
1Etablissement Français du Sang Alpes-Méditerranée, Marseille, France. pierre.gallian@efs.sante.fr
Background And Objective:
In order to prevent West Nile virus (WNV) contaminations by transfusion, the French National Blood Service decided to evaluate the INTERCEPT Blood System's efficiency on a European strain.
Materials And Methods:
Culture supernatant of WNV was used to infect six platelets concentrates. Viral titre was determined by plaque reduction neutralization test before and after viral inactivation using the INTERCEPT Blood System.
Results:
In all assays, the absence of plaque forming unit was observed after viral inactivation. The log reduction observed ranged between > 5.1 logs to > 5.2 logs.
Conclusion:
INTERCEPT Blood System is a commercially viral inactivation method potentially useful in order to prevent WNV transmission by blood products in France during re-emerging outbreaks.
