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Related Experiment Video

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Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

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Published on: April 12, 2019

Database for chicken full-length cDNAs.

Yong Wang¹, Zhenggang Wang, Juan Li

¹Department of Zoology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

Physiological Genomics

|November 16, 2006

Summary

A new chicken full-length cDNA database aids functional genomics and gene annotation. This resource aligns chicken expressed sequence tags (ESTs) with human and mouse data, supporting animal science research.

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Area of Science:

Genomics
Bioinformatics
Comparative Genomics

Background:

Full-length cDNA databases are crucial for functional genomics and accurate genome annotation.
Human and mouse cDNA projects have significantly advanced biomedical research.
The availability of the chicken genome sequence draft allows for similar initiatives in avian research.

Purpose of the Study:

To develop a comprehensive chicken full-length cDNA database.
To facilitate future research in avian functional genomics and annotation.
To provide a valuable resource for animal science and veterinary researchers.

Main Methods:

Alignment of chicken expressed sequence tags (ESTs) against human and mouse full-length cDNAs.
Utilized over 588,000 chicken ESTs and approximately 170,000 human/mouse cDNA templates from NEDO, RIKEN, and MGC databases.
Integrated orthologous chicken gene information from the EMBL database.

Main Results:

Successfully aligned a large number of chicken ESTs to known mammalian full-length cDNAs.
Established a database containing aligned ESTs, full-length mammalian templates, and orthologous chicken gene information.
The database is accessible online at http://bioinfo.hku.hk/chicken/.

Conclusions:

The developed chicken full-length cDNA database is a significant resource for the research community.
This database will aid in cloning and confirming full-length chicken cDNAs of interest.
Ongoing updates will ensure the database remains a current and valuable tool for avian research.