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Related Experiment Video

Updated: Jul 18, 2026

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

Published on: March 11, 2017

Drug compatibility with new polyolefin infusion solution containers.

Lawrence A Trissel¹, Quanyun A Xu, Mary Baker

¹TriPharma Research, Cashiers, NC 28717-0265, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|November 16, 2006

Summary

New polyolefin (VISIV) containers show good compatibility with most drugs. Only regular human insulin exhibited significant sorption, while no leached plasticizers were detected in VISIV containers, unlike with polyvinyl chloride (PVC).

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Area of Science:

Pharmaceutical packaging materials science
Drug compatibility studies
Polymer science

Background:

Polyvinyl chloride (PVC) containers can cause drug sorption and plasticizer leaching.
New polyolefin (VISIV) containers offer a potential alternative for drug storage.
Assessing drug compatibility is crucial for maintaining therapeutic efficacy and patient safety.

Purpose of the Study:

To evaluate the compatibility of new polyolefin (VISIV) containers.
To assess drug sorption and plasticizer leaching with VISIV containers.
To compare VISIV container performance against known issues with PVC.

Main Methods:

Tested seven drugs known for sorption to PVC and four drugs known for leaching from PVC.
Used high-performance liquid chromatography (HPLC) for quantitative analysis.
Stored drug admixtures in VISIV containers under ambient conditions with fluorescent light exposure.

Main Results:

Regular human insulin showed substantial sorption in VISIV containers.
Carmustine loss was consistent with its known chemical instability.
No leached plastic components, including diethylhexyl phthalate (DEHP), were detected in VISIV containers.

Conclusions:

VISIV polyolefin containers demonstrated good compatibility with most tested drugs.
Only regular human insulin exhibited significant sorption.
No plasticizer leaching was observed from VISIV containers, indicating improved safety over PVC for certain drugs.