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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Helicobacter pylori infection with a duodenal ulcer in a 6-year-old boy
Miharu Hajikano1, Yasuhiro Katsube, Yuko Takita
1Department of Pediatrics, Nippon Medical School Graduate School of Medicine, Kanagawa, Japan. miharu@nms.ac.jp
Insights
A pediatric case of peptic ulcer disease linked to Helicobacter pylori infection highlights the efficacy of stool antigen testing in children. Successful eradication therapy was confirmed using this reliable diagnostic method.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
Background:
- Peptic ulcer disease (PUD) is uncommon in young children but can present with gastrointestinal bleeding.
- Iron-deficiency anemia and occult gastrointestinal bleeding are potential manifestations of PUD in pediatric patients.
Observation:
- A 6-year-old boy presented with anemia, dark stools, and fatigue, indicative of gastrointestinal blood loss.
- Endoscopic examination revealed gastric erosions and a duodenal ulcer.
- Multiple diagnostic tests confirmed active Helicobacter pylori infection.
Findings:
- Helicobacter pylori infection was diagnosed in a pediatric patient presenting with symptoms of anemia and gastrointestinal bleeding.
- The patient's father had a history of H. pylori-associated gastric ulcer, suggesting potential familial transmission.
- Triple-agent eradication therapy successfully treated the H. pylori infection and resolved the peptic ulcer disease.
Implications:
- This case underscores that peptic ulcer disease can occur in young children.
- The stool antigen test is a valuable and reliable tool for diagnosing H. pylori infection in preschool-aged children.
- Early diagnosis and treatment of H. pylori infection are crucial for managing PUD in pediatric populations.
Abstract:
A 6-year-old boy was hospitalized because of dark feces and facial pallor of 1 weeks duration. Other gastrointestinal symptoms, including vomiting and abdominal pain, were absent, but he felt dizziness when standing and fatigue on effort. Hematologic studies revealed iron-deficiency anemia, and endoscopy showed gastric erosions and a duodenal ulcer. All test results for Helicobacter pylori infection, including H. pylori antigen in stool, anti-H. pylori IgG immunoassay in serum, and the (13)C-urea breath test, were positive. Because an H. pylori-associated gastric ulcer had been diagnosed with endoscopy in the patients father 3 years earlier, father-son transmission was suspected. The patient was treated with triple-agent eradication therapy (proton pump inhibitor [lansoprazol], amoxicillin, and clarithromycin) for 2 weeks. One month after therapy was completed, eradication of H. pylori was confirmed by negative results on the stool antigen test. Peptic ulcer disease can occur in young children, as in this case. The stool antigen test kit is a useful and reliable method that can be used even in preschool children to diagnose H. pylori infection.
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