Related Experiment Video

Updated: Jul 18, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Cyclin D1 functions in cell migration

Zhiping Li1, Chenguang Wang, George C Prendergast

  • 1Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Cell Cycle (Georgetown, Tex.)
|November 16, 2006
PubMed

Insights

Cyclin D1 promotes cancer cell migration by inhibiting Rho/ROCK signaling and thrombospondin-1 (TSP-1) expression. This suggests a key role for cyclin D1 in cancer invasion and metastasis.

Area of Science:

  • Cell biology
  • Cancer research
  • Molecular signaling

Background:

  • Cell migration is crucial for development, repair, and metastasis.
  • Overexpression of cyclin D1 is common in cancers, driven by oncogenes.
  • Thrombospondin-1 (TSP-1) is an extracellular matrix protein influencing cell migration.

Purpose of the Study:

  • To investigate the role of cyclin D1 in regulating cell migration.
  • To elucidate the molecular mechanisms by which cyclin D1 affects cell migration, specifically its relationship with Rho/ROCK signaling and TSP-1.

Main Methods:

  • The study likely involved cell-based assays to measure migration.
  • Analysis of signaling pathways, including Rho/ROCK, was performed.
  • Expression levels of cyclin D1 and TSP-1 were assessed.

Main Results:

  • Cyclin D1 was found to inhibit Rho/ROCK signaling.
  • Cyclin D1 suppressed the expression of thrombospondin-1 (TSP-1).
  • These actions collectively promote cell migration.

Conclusions:

  • Cyclin D1 plays a significant role in promoting cell migration.
  • By inhibiting Rho/ROCK signaling and TSP-1, cyclin D1 facilitates cancer cell invasion and metastasis.
  • Targeting cyclin D1 may offer therapeutic strategies for cancer metastasis.

More Related Videos

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...