Related Experiment Video

Updated: Jul 18, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

HLA-DRB1* alleles in Egyptian children with post-streptococcal acute glomerulonephritis

Ashraf Bakr1, Lotfi Abdel-Naby Mahmoud, Farha Al-Chenawi

  • 1Pediatric Nephrology, Mansoura University Children's Hospital, Goumhoria Street, Mansoura, 35516, Egypt. ashbakr@mans.edu.eg

Pediatric Nephrology (Berlin, Germany)
|November 16, 2006
PubMed

Insights

The HLA-DRB1* 03011 allele is linked to an increased risk of post-streptococcal acute glomerulonephritis (PSAGN) in Egyptian children. This genetic association suggests susceptibility but does not influence disease severity.

Area of Science:

  • Immunogenetics
  • Pediatric Nephrology
  • Molecular Epidemiology

Background:

  • Post-streptococcal acute glomerulonephritis (PSAGN) is a significant kidney disease in children.
  • Genetic factors, particularly Human Leukocyte Antigen (HLA) alleles, are implicated in PSAGN susceptibility.
  • Understanding these genetic associations can inform disease prevention and management strategies.

Purpose of the Study:

  • To investigate the association between specific HLA-DRB1* alleles and the risk of developing PSAGN in Egyptian children.
  • To determine if certain HLA-DRB1* alleles are more prevalent in children with PSAGN compared to healthy controls.
  • To explore potential correlations between HLA-DRB1* allele frequencies and disease severity markers like hypertension and proteinuria.

Main Methods:

  • Case-control study involving 32 Egyptian children diagnosed with PSAGN and 380 healthy controls.
  • HLA-DRB1* allele typing performed using polymerase chain-reverse hybridization.
  • Statistical analysis to compare allele frequencies and calculate relative risks, including P-value corrections.

Main Results:

  • A significantly higher frequency of HLA-DRB1* 03011 (46.9% vs. 19.2%) and HLA-DRB1* 1105 (31.1% vs. 15.6%) was observed in PSAGN patients compared to controls.
  • After correcting for multiple comparisons, only the association with HLA-DRB1* 03011 remained statistically significant (Pc=0.025).
  • Both alleles showed significantly high relative risks, indicating increased susceptibility, but no correlation was found between these alleles and the grades of hypertension or proteinuria.

Conclusions:

  • The HLA-DRB1* 03011 allele confers a significant susceptibility to developing PSAGN in Egyptian children.
  • The HLA-DRB1* 1105 allele may also play a role in PSAGN susceptibility, though its association was not significant after statistical correction.
  • These specific HLA-DRB1* alleles do not appear to determine the severity of PSAGN, as indicated by the lack of association with hypertension or proteinuria levels.

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...