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Software package for integrated data processing for internal dose assessment in nuclear medicine (SPRIND).

Eric Visser¹, Ernst Postema, Otto Boerman

¹Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. e.visser@nucmed.umcn.nl

European Journal of Nuclear Medicine and Molecular Imaging

|November 16, 2006

Summary

A new software package, SPRIND, simplifies internal radiation dose assessment in nuclear medicine by calculating radiopharmaceutical residence times from scintigrams. This tool enhances accuracy and efficiency in dose calculations, making studies less time-consuming and error-prone.

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Area of Science:

Nuclear Medicine
Medical Physics
Radiopharmaceutical Dosimetry

Background:

Internal radiation dose calculations commonly use the Medical Internal Radiation Dose (MIRD) schema, requiring organ residence times and S-values.
Quantitative nuclear imaging can determine residence times, while software like MIRDOSE and OLINDA/EXM handle S-values.
Existing software lacks the capability to derive residence times directly from imaging data.

Purpose of the Study:

To develop an integrated software package for internal dose assessment in nuclear medicine.
To enable calculation of radiopharmaceutical residence times from quantitative imaging data.
To streamline the process of internal radiation dose calculations.

Main Methods:

Developed an IDL-based software package named SPRIND for integrated data processing.
SPRIND processes planar whole-body scintigrams, allowing organ and background region definition.
Calculates residence times using effective decay and incorporates a voiding bladder model; results are output in MIRDOSE-OLINDA/EXM format.

Main Results:

SPRIND enables reading, viewing, and processing of scintigrams, including automatic mirroring of regions of interest.
Calculates organ residence times, total body biological half-time, and red bone marrow absorbed dose.
The software is gamma camera vendor-independent and runs on any computer with an IDL virtual machine.

Conclusions:

SPRIND is an user-friendly software package for radiation dose assessment.
The package significantly reduces the time and potential for errors in dose assessment studies.
Facilitates more efficient and accurate internal dosimetry in nuclear medicine practices.