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Updated: Jul 18, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
Lipases in beta-dipeptide synthesis in organic solvents
Xiang-Guo Li1, Liisa T Kanerva
1Department of Pharmacology, Drug Development and Therapeutics/Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, Lemminkaisenkatu 5C, FIN- 20520 Turku, Finland.
Abstract:
A number of beta-dipeptides were prepared by two-step lipase-catalyzed reactions where N-acetylated beta-amino esters were first activated as 2,2,2-trifluoroethyl esters with Candida antarctica lipase B (CAL-B). The activated esters were then used to acylate beta-amino ester in the presence of Candida antarctica lipase A (CAL-A) in dry Et2O or i-Pr2O. [reaction: see text].
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