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Updated: Jul 17, 2026
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Development of a stereoselective co-mediated dihydropyran ring contraction
Simon J Meek1, Fabienne Pradaux, Emmanuel H Demont
1Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
Abstract:
A highly stereoselective approach for the synthesis of trans-1,2-disubstituted cyclobutanes through an Al-promoted cobalt-mediated O-->C ring contraction of dihydropyrans is described. [reaction: see text].
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