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Flip-flop in adsorbed bilayers.

Abbas Khan1, William A Ducker, Min Mao

  • 1Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, VIC 3010 Australia.

The Journal of Physical Chemistry. B
|November 17, 2006
PubMed
Summary

Adsorbed bilayers exhibit extremely rapid molecular exchange and flip-flop, occurring within seconds. This contrasts sharply with vesicles, suggesting surface-induced defects facilitate fast flip-flop in supported lipid bilayers.

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Area of Science:

  • Surface chemistry
  • Interface science
  • Materials science

Background:

  • Adsorbed lipid bilayers are crucial in biological interfaces and nanotechnology.
  • Understanding molecular dynamics within supported bilayers is key to their function.
  • Previous studies indicated slow flip-flop in vesicles, but adsorbed systems remained less understood.

Purpose of the Study:

  • To investigate the molecular exchange and flip-flop rates in adsorbed lipid bilayers.
  • To compare the dynamics of adsorbed bilayers with those of free vesicles.
  • To elucidate the mechanisms governing molecular transport across supported bilayers.

Main Methods:

  • Utilized infrared spectroscopy for independent monitoring of labeled and unlabeled surfactants.
  • Employed an internal reflection configuration for surface selectivity.
  • Analyzed exchange kinetics of both inner and outer layers of the bilayer.

Main Results:

  • Demonstrated complete molecular exchange of adsorbed bilayers within seconds.
  • Observed extremely fast exchange of the inner layer into surfactant solution when a bilayer is present.
  • Showcased that desorption of a monolayer into water is exceptionally slow.

Conclusions:

  • Adsorbed bilayers exhibit very rapid flip-flop, contrasting with the slow rates in vesicles.
  • Hypothesized that surface-induced defects in adsorbed layers accelerate flip-flop.
  • Surface pressure in vesicles may close defects, inhibiting rapid flip-flop.

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