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Related Experiment Videos

Leflunomide-induced peripheral neuropathy.

L K Kho1, A G Kermode

  • 1Department of Neurology, Royal Perth Hospital, Western Australia.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|November 17, 2006
PubMed
Summary
This summary is machine-generated.

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Leflunomide, a medication for autoimmune conditions, may cause peripheral neuropathy. Stopping the drug led to symptom and nerve function improvement in two patients, suggesting this side effect may be under-recognized.

Area of Science:

  • Neurology
  • Rheumatology
  • Pharmacology

Background:

  • Leflunomide is an immunosuppressive disease-modifying antirheumatic drug (DMARD) used for rheumatoid arthritis and other autoimmune conditions.
  • Peripheral neuropathy is a potential adverse effect of various medications, but its association with leflunomide is not well-established.

Observation:

  • Two patients, a 60-year-old woman with polyarthralgia-myalgia syndrome and a 65-year-old man with rheumatoid arthritis, developed sensorimotor axonal neuropathy while on leflunomide 20mg/day.
  • Investigations, including cerebrospinal fluid analysis and nerve biopsy, ruled out alternative causes for the neuropathy.

Findings:

  • Nerve conduction studies and electromyography confirmed sensorimotor axonal neuropathy in both cases.
  • Discontinuation of leflunomide resulted in symptomatic and electrophysiological stabilization in both patients.

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Implications:

  • This report suggests leflunomide may induce peripheral neuropathy, a side effect potentially under-recognized in clinical practice.
  • Awareness of this adverse effect is crucial for timely diagnosis and management in patients treated with leflunomide.