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Related Experiment Video

Updated: Jul 18, 2026

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

S100A1 gene transfer in myocardium.

S T Pleger1, P Most, B Heidt

  • 1Department of Internal Medicine III, Division of Cardiology, University of Heidelberg, Otto-Meyerhof-Zentrum, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany. sven.pleger@jefferson.edu

European Journal of Medical Research
|November 17, 2006
PubMed
Summary

Gene delivery of S100A1 protein to the heart improves cardiac function. This study shows that S100A1 gene therapy can enhance heart performance, offering a potential treatment for heart failure.

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Gene Therapy

Background:

  • S100A1 protein regulates cardiac contractility and calcium handling.
  • S100A1 expression is decreased in human heart failure.
  • S100A1 expression is increased in compensated hypertrophy.

Purpose of the Study:

  • To investigate the feasibility of exogenous S100A1 gene delivery to the normal rabbit heart.
  • To assess the impact of S100A1 overexpression on global cardiac function.
  • To explore S100A1 gene therapy as a potential strategy for heart failure.

Main Methods:

  • Adenoviral vector (AdvS100A1) encoding S100A1 and GFP delivered via intracoronary injection.
  • Control groups received GFP-only adenovirus (AdvGFP) or saline.

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Related Experiment Videos

Last Updated: Jul 18, 2026

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
06:03

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice
08:03

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Published on: March 30, 2022

  • Hemodynamic parameters assessed 7 days post-gene delivery, including response to isoproterenol.

    • Main Results:

    • S100A1 overexpression significantly increased left ventricular +dP/dt max, -dP/dt min, and systolic ejection pressure under isoproterenol stimulation.
    • Cardiac contractile parameters remained unchanged under basal conditions.
    • Global myocardial in vivo gene delivery was demonstrated as feasible.

    Conclusions:

    • Myocardial S100A1 overexpression enhances cardiac performance.
    • S100A1 gene delivery is a viable strategy for improving cardiac function.
    • Replacing down-regulated S100A1 may be a therapeutic approach for heart failure.