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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 30, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
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The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Proteomics in renal research.

Michael G Janech1, John R Raymond, John M Arthur

  • 1Medical University of South Carolina, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29425-2220, USA.

American Journal of Physiology. Renal Physiology
|November 17, 2006
PubMed
Summary
This summary is machine-generated.

Proteomic technologies are increasingly used in kidney research to identify disease-specific proteins and biomarkers. These advanced methods, combined with traditional techniques, promise significant discoveries in renal science.

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Last Updated: Jun 30, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
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Area of Science:

  • Nephrology
  • Proteomics
  • Biomarker Discovery

Background:

  • Proteomic technologies are increasingly adopted within the renal research community.
  • Understanding kidney function and disease relies on analyzing the proteome.

Purpose of the Study:

  • To review the application of various proteomic techniques in renal research.
  • To highlight the potential of these technologies for advancing kidney science.

Main Methods:

  • Two-dimensional gel electrophoresis
  • Liquid chromatography/mass spectrometry
  • Surface-enhanced laser desorption/ionization
  • Capillary electrophoresis/mass spectrometry
  • Antibody and tissue arrays

Main Results:

  • Identification of proteins specific to kidney regions.
  • Detection of protein changes associated with renal diseases or toxicity.
  • Examination of protein expression and posttranslational modifications in signaling pathways.
  • Application of proteomic methodologies for diagnostic biomarker discovery in body fluids.

Conclusions:

  • Proteomic technologies offer powerful tools for renal research.
  • The rapid advancement of these techniques will drive new discoveries in nephrology.
  • Integrating proteomics with traditional methods enhances understanding of kidney physiology and pathology.