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Updated: Jul 18, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
Published on: May 28, 2021
Modelling epidermal homeostasis as an approach for clinical bioinformatics
Niels Grabe1, Thora Pommerencke, Dennis Müller
1Department of Medical Informatics, University Hospital Heidelberg, Germany. niels.grabe@med.uni-heidelberg.de
Abstract:
Modelling in systems biology currently lacks clinical applications. As a possible approach leading to clinical relevance the modelling of tissue homeostasis is proposed. As an example a model of epidermal homeostasis is presented which reproduces central morphological and kinetic characteristics of epidermal tissue. Each individual cell is modelled as an agent. The tissue arises as an emergent phenomenon from the interactions of agents. Each agent's behaviour is qualitatively modelled by a simple differentiation state-flow program. Epithelialisation under the influence of parameters concerning stem-cell location is briefly demonstrated.
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