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Updated: Jul 15, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Computational representation of Alzheimer's disease evolution applied to a cooking activity
Audrey Serna1, Vincent Rialle, Hélène Pigot
1TIMC-IMAG UMR CNRS 5525 Laboratory, Grenoble, France. Audrey.Serna@imag.fr
Abstract:
This article presents a computational model and a simulation of the decrease of activities of daily living performances due to Alzheimer's disease. The disease evolution is simulated thanks to the cognitive architecture ACT-R. Activities are represented according to the retrieval of semantic units in declarative memory and the trigger of rules in procedural memory. The simulation of Alzheimer's disease decrease is simulated thanks to the variation of subsymbolic parameters. The model is applied to a cooking activity. Simulation of 100 hundred subjects shows results similar to those realised in a standardized assessment with human subjects.
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